Predict, prevent and manage moral injuries in Canadian frontline healthcare workers and leaders facing the COVID-19 pandemic: Protocol of a mixed methods studyResearch article Published on 2022-12-012022-10-05 Journal: SSM - Mental Health [Category] 바이오마커, [키워드] addition adjusted analysis Biomarker Biomarkers blood sample build collected condition contribute COVID-19 COVID-19 crisis COVID-19 pandemic develop disease emotional event expand frontline healthcare worker generate group Health healthcare healthcare worker Healthcare workers identify Inflammation Injury knowledge mental health Moral Moral injuries observé occur Occurrence participant predict predictor Prevent protocol psychosocial stressor Psychosocial stressors at work Quantitative Quantitative data questionnaire recommendation reduce Research risk Risk factors severity Stress Stressor [DOI] 10.1016/j.ssmmh.2022.100124 [Article Type] Research article
Label-free Sensing of Main Protease Activity of SARS-CoV-2 with an Aerolysin NanoporeArticle Published on 2022-11-022022-11-15 Journal: Chemistry, an Asian journal [Category] SARS, 치료기술, [키워드] activity acute respiratory syndrome amplification Biomarker cleavage cleaved Concentration conserved coronavirus Critical diagnostic enzyme events exhibited expand M pro MPro Nanopore peptide produced protease Replication SARS-CoV-2 sensitivity sensors. translocated viruses [DOI] 10.1002/asia.202200747 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
A precise review on NAATs-based diagnostic assays for COVID-19: A motion in fast POC molecular testsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Investigation [Category] SARS, 치료기술, [키워드] addressed advance approved assist authorization Care Comparative coronavirus disease COVID-19 diagnostic Diagnostic method disease Emergency expand false-negative global pandemic Health limitation mitigate molecular molecular diagnostic assays molecular test NAAT New nucleic acid amplification nucleic acid amplification techniques parameter platform POC POC testing point-of-care Point-of-care testing. polymerase chain RT-qPCR SARS-CoV-2 Sensitivity and specificity suggested [DOI] 10.1111/eci.13853 PMC 바로가기
Impact of COVID-19 on the lives and mental health of children and adolescentsArticle Published on 2022-10-182022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adolescent affected age Anxiety children Complete concerning COVID-19 COVID-19 pandemic Digital disease European expand GAD Generalized greater Health help higher education Impact introduced Local lockdown major depressive disorder mental health mental health issue mental health service outcomes pandemic physical distancing Prevalence questionnaire reflected significantly social life. spread of COVID-19 Stress student survey therapeutic union [DOI] 10.3389/fpubh.2022.925213 PMC 바로가기
Susceptibility to Resurgent COVID-19 Outbreaks Following Vaccine Rollouts: A Modeling StudyArticle Published on 2022-10-122022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Asymptomatic Characteristics compartmental model conditions contagious country Coverage COVID-19 COVID-19 vaccine COVID-19 vaccines Effect Effectiveness Endemic Epidemics epidemiological expand explain Health help Immunity include initial key factor modeling parameter populations reported resurgent epidemics SARS-CoV-2 SARS-CoV-2 variants Spread susceptibility the disease the SARS-CoV-2 virus the vaccine vaccination vaccination coverage waning immunity Waning Immunity. [DOI] 10.3390/v14102237 PMC 바로가기
Inactivation of SARS-CoV-2 and photocatalytic degradation by TiO2 photocatalyst coatingsArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] acetaldehyde acute respiratory syndrome addition antiviral activity approach catalytic activity Contact coronavirus COVID-19 decrease Degradation effective Epidemic expand feature formaldehyde global pandemic inactivation Influenza virus investigated purification reached SARS-CoV-2 SEM significantly the epidemic transmitted virus [DOI] 10.1038/s41598-022-20459-2 PMC 바로가기
Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severityArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] 바이오마커, 변종, [키워드] Amino acid amino acids analysed Analysis C-reactive protein Clinical diagnosis Clinical severity clinical suspicion Clinical tests collected COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Diagnosis diagnostic Disease progression driver dysregulation eliminating expand exploratory feature Health hospital hospitalised patient likelihood marker metabolomics Metadata Non-invasive offer outcomes Patient patients peripheral oxygen saturation Prognosis progressed receiver operating characteristics recent Research reservoir respiratory rate resulting reveal RT-PCR testing Saliva saliva sample serum severity shown the disease Treatment Vaccine variants [DOI] 10.1371/journal.pone.0274967 PMC 바로가기
Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody libraryArticle Published on 2022-09-162022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] accelerated affinity Affinity maturation amplification antibodies antibody binding CDR Cdr1 CDR2 COVID-19 COVID-19 pandemic Electroporation expand fusion protein humanized IC50 Isolation moderate Mutagenesis Mutation nanobody neutralization Neutralizing omicron performed plaque reduction neutralization PRNT randomization RBD Reactions Receptor binding domain robust SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 variant SARS-CoV-2 variants subsequent synthetic library. therapeutic potential trimeric Vaccine development variant VHH [DOI] 10.3389/fimmu.2022.965446 PMC 바로가기
Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infectionArticle Published on 2022-09-022022-11-16 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] Acinetobacter acquisition antimicrobial drug Bacteremia Bacterial bloodstream infection caused change characteristic COVID-19 pandemic Critical curtail dissemination essential nutrient evaluated exhibited expand expression expression pattern feasible gene encoding Gene Expression Gram-negative bacteremia growth Health healthcare homeostasis Host host gene expression Immunity impairment include induce Infection inhibit inhibiting innate immune response involved lack Lcn2 lipocalin-2 MDR mechanism mice Mortality multidrug resistant multifactorial organ organ-specific pathogen Pneumonia Prevalence proliferation Protective Protein required reveal robust S100A8 S100A9 secondary bacterial pneumonia sequestering survival target therapeutic tissues Transcription transcriptional Treatment upregulated ventilated patient Ventilator-associated pneumonia were infected World Health Organization [DOI] 10.1371/journal.ppat.1010809 PMC 바로가기